细胞生物学

Scientists in blue lab coats and face masks are working in a row at laboratory benches, focusing on genetic toxicology. They use pipettes, containers, and other lab equipment under a sterile hood. The lab environment appears clean and organized.

细胞生物学服务

康龙化成的细胞生物学团队汇聚了众多在不同疾病领域经验丰富的细胞生物学研究专家。

我们在生物模型的选择与应用方面具备深厚的专业能力,涵盖基因改造细胞模型、肿瘤细胞、原代细胞以及复杂的生物体系(如2D/3D培养、共培养、类器官等)。同时,我们在与疾病相关的靶点和信号通路研究上也有着深入的见解。

凭借细胞生物学团队强大的检测平台,我们能够为客户提供定制化的精准解决方案。服务范围包括但不限于:细胞层面的靶点结合情况分析,与疾病相关的多种表型检测,功能性检测,下游信号通路的探索,作用机制及耐药机制研究等。我们致力于为临床前实验提供坚实且全面的数据支持,从化合物活性到选择性/脱靶分析的安全性评价,助力客户的研发项目顺利推进。

细胞模型

  • 人类肿瘤细胞系
  • 人类正常细胞系
  • 啮齿类动物肿瘤细胞系
  • 类器官
  • 原代细胞(全血、多种免疫细胞、胰岛细胞、小胶质细胞等)
  • 耐药细胞系
  • 诱导多能干细胞(心肌细胞、神经元等)
  • 工程细胞系

为各类细胞检测实验的开发提供全面技术支持。

The operetta high-content imaging system is used for cell biology services

表型筛选

  • 基于单层细胞、3D球体、类器官和共培养的检测
  • 原代细胞和干细胞检测
  • 高内涵及实时成像
  • 细胞全景绘制
  • 细胞疾病模型
    • 肿瘤学
    • 神经学
    • 免疫学
    • 代谢紊乱
    • 心血管疾病
    • 纤维化
Cell-based functional assays are performed with state-of-the-art instrumentation such as the SynchroPatch.

细胞功能检测

  • 氧化应激
  • 膜电位、电流及场电位
  • 离子通量
  • 蛋白质降解
  • 翻译后修饰
  • 第二信使
  • 细胞形态
  • 细胞激活与分化
  • 细胞器
  • 细胞代谢
  • 细胞迁移
  • 蛋白定位和易位
  • DNA损伤和修复
Mesoscale discovery is employed to study the mode of action after performing cell-based functional assays.

作用机制(MoA)研究

下游功能与信号通路检测

Gloved hands handling an xMAP Technology automated maintenance plate used in biochemistry for high-throughput analysis.

靶点结合研究

  • 靶点的NanoBRET检测
  • 基于NanoBiT的蛋白相互作用分析
  • 基于荧光探针的高内涵测定
  • 放射性配体结合实验
  • 基于多种检测方式的细胞热位移测定
  • 流式细胞术
  • 质谱分析
Bioinformatics are required to analyze the complex data sets created when performing phenotypic screening.

生物信息学

  • 分子对接
  • 基因组学分析
  • 蛋白质组学分析
  • 图像分析
  • 建模与机器学习
  • 预测性指标评估
Digital poster titled "Mechanism of BRAF Inhibitor Resistance Revealed by Cell Panel Screening and Bioinformatics," featuring charts and graphs. Accompanied by the text "Download Below" and the Pharmaron logo in the bottom right corner, this resource delves into genetic toxicology insights.

BRAF抑制剂耐药机制

A brochure cover showcasing Pharmaron's Fully Automated High-Throughput Screening Services. The left side has an image of a technician working with automated equipment used in Preclinical ADME studies. The right side features a "Download Below" call to action.

全自动高通量筛选服务

Conference poster by Pharmaron discussing the importance of linking activity across multiple in vitro assays for molecule understanding and progression.

多种体外测定的活性关联

Cancer cell panel screening services overview, featuring customizable plate layouts, validated cancer cell panel options, and PDF download from Pharmaron's cell panel screening service.

癌细胞系组合筛选服务

Scientists in blue lab coats and face masks are working in a row at laboratory benches, focusing on genetic toxicology. They use pipettes, containers, and other lab equipment under a sterile hood. The lab environment appears clean and organized.

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