Discovery and Optimisation of Molecular Glues: Concepts and Case Studies

18 June 2025

8 am PT / 11 am ET / 4 pm GMT

Join Pharmaron and leading experts in drug discovery for a deep dive into the emerging field of molecular glues—small molecules that induce or stabilize protein–protein interactions (PPIs) to achieve targeted protein degradation or modulation. This insightful session will explore the history, mechanisms, and translational potential of molecular glue degraders, with real-world case studies that highlight innovative approaches to hit identification and characterization.

Attendees will gain a comprehensive understanding of:

• Molecular Glue Overview
  • What are molecular glues?
  • A brief history and key examples
  • Molecular glue degraders
  • Approaches to identification
• SLP76/14-3-3 PPI stabiliser/degrader case study
  • Hit identification and follow-up using biophysics

Moderated by:

Chris Wellaway - Associate Director, Medicinal Chemistry, Drug Discovery at Pharmaron

Speakers:

• Marta Westwood - Director/Senior Principal Scientist, Biophysics at Pharmaron
• Amy Brown - Biologist, Drug Discovery Services at Pharmaron