An advertisement poster for Pharmaron featuring a research paper on human PK prediction strategy incorporating calibrated hepatocyte clearance assays. The poster includes small text and graphs with a "Download Below" button on the right. Pharmaron's logo is at the bottom right.

Human PK prediction strategy incorporating calibrated hepatocyte clearance assays: Verifying the approach using examples from Phase 1

Our poster discusses our strategies and methodology to support small molecule development by providing reliable predictions of human PK. This is an essential step to select compounds in the discovery phase and to prepare for phase 1 trial dosing.

In this poster you can find out more about the human PK prediction strategy:

  • Our strategic approach for scaling human PK parameters from pre-clinical data including metabolic clearance, volume of distribution, and absorption
  • Our improved approach for scaling metabolic clearance using calibrated in vitro hepatocyte systems
  • Comparison of predicted parameters with observed Phase 1 data for two small molecules showing predictions within 2-fold